Shelley and Yaniv Brandvain developed forward evolutionary simulation models (using SLiM) to examine the evolution of genetic load in relation to mating system variation. This was a massive effort to improve upon our understanding of how processes interact to determine how mating system transitions affect the efficacy of selection.

Sianta, S.A., S. Peischl, D.A. Moeller, & Y. Brandvain. 2023. The efficacy of selection may increase or decrease with selfing depending upon the recombination environment. Evolution 77:394-408.

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